From Amerigo Vespucci Airport you have three convenient options to reach us:

Volainbus shuttle → available every 30 minutes from 5:30 a.m. and will take you directly to Santa Maria Novella station
Tramway T2 → an environmentally friendly option that takes you to Santa Maria Novella station from 5 a.m. until midnight
Cab → you will find cabs at the airport exit for a convenient and quick transfer

The center of Florence is a Restricted Traffic Zone and, therefore, direct access is not allowed. But there are two excellent solutions:

Free parking → you can park for free in the Stadium area or in Piazzale Michelangelo, a short distance from the center
Private parking in the center → many private parking lots offer permission to enter the ZTL